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Abandoned drugs
Tofenacin
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Tofenacin

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Tofenacin
Tofenacin.svg
Clinical data
Trade names Elamol, Tofacine, Tofalin
Other names tofenacin hydrochloride (USAN US)
Routes of
administration		 By mouth
ATC code
  • None
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • N-methyl-2-[(2-methylphenyl)(phenyl)methoxy]ethanamine
CAS Number
PubChem CID
ChemSpider
UNII
ECHA InfoCard 100.035.746
Chemical and physical data
Formula C17H21NO
Molar mass 255.361 g·mol−1
3D model (JSmol)
  • O(CCNC)C(c1ccccc1)c2ccccc2C
  • InChI=1S/C17H21NO/c1-14-8-6-7-11-16(14)17(19-13-12-18-2)15-9-4-3-5-10-15/h3-11,17-18H,12-13H2,1-2H3
  • Key:PNYKGCPSFKLFKA-UHFFFAOYSA-N

Tofenacin is an antidepressant drug with a tricyclic-like structure which was developed and marketed in the United Kingdom and Italy in 1971 and 1981, respectively, by Brocades-Stheeman & Pharmacia (now part of Astellas Pharma). It acts as a serotonin-norepinephrine reuptake inhibitor, and based on its close relation to orphenadrine, may also possess anticholinergic and antihistamine properties. Tofenacin is also the major active metabolite of orphenadrine and likely plays a role in its beneficial effects against depressive symptoms seen in Parkinson's disease patients.

See also




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