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Respiratory system drug stubs
Chlorcyclizine
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Chlorcyclizine

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Chlorcyclizine
Chlorcyclizine.png
Clinical data
AHFS/Drugs.com International Drug Names
MedlinePlus a682619
Routes of
administration		 Oral
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • 1-[(4-Chlorophenyl)(phenyl)methyl]-4-methylpiperazine
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.001.315
Chemical and physical data
Formula C18H21ClN2
Molar mass 300.83 g·mol−1
3D model (JSmol)
  • Clc1ccc(cc1)C(c2ccccc2)N3CCN(CC3)C
  • InChI=1S/C18H21ClN2/c1-20-11-13-21(14-12-20)18(15-5-3-2-4-6-15)16-7-9-17(19)10-8-16/h2-10,18H,11-14H2,1H3 checkY
  • Key:WFNAKBGANONZEQ-UHFFFAOYSA-N checkY
  (verify)

Chlorcyclizine (Di-Paralene, Mantadil, Pruresidine, Trihistan) is a first-generation antihistamine of the diphenylmethylpiperazine group marketed in the United States and certain other countries. It is used primarily to treat allergy symptoms such as rhinitis, urticaria, and pruritus, and may also be used as an antiemetic. In addition to its antihistamine effects, chlorcyclizine also has some anticholinergic, antiserotonergic, and local anesthetic properties. It also has been studied as a potential treatment for various flaviviruses like Hepatitis C and Zika Virus.


See also



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