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Anticonvulsant
Tracazolate
Другие языки:

    Tracazolate

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    Not to be confused with cartazolate.
    Tracazolate
    Tracazolate.svg
    Clinical data
    Routes of
    administration    		 By mouth
    ATC code
    • None
    Legal status
    Legal status
    • In general: uncontrolled
    Identifiers
    • Ethyl 4-(butylamino)-1-ethyl-6-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate
    CAS Number
    PubChem CID
    IUPHAR/BPS
    ChemSpider
    UNII
    KEGG
    ChEBI
    ChEMBL
    CompTox Dashboard (EPA)
    ECHA InfoCard 100.050.178
    Chemical and physical data
    Formula C16H24N4O2
    Molar mass 304.394 g·mol−1
    3D model (JSmol)
    • O=C(OCC)c1c(c2c(nc1C)n(nc2)CC)NCCCC
    • InChI=1S/C16H24N4O2/c1-5-8-9-17-14-12-10-18-20(6-2)15(12)19-11(4)13(14)16(21)22-7-3/h10H,5-9H2,1-4H3,(H,17,19)
    • Key:PCTRYMLLRKWXGF-UHFFFAOYSA-N

    Tracazolate (ICI-136,753) is an anxiolytic drug which is used in scientific research. It is a pyrazolopyridine derivative, most closely related to pyrazolopyrimidine drugs such as zaleplon, and is one of a structurally diverse group of drugs known as the nonbenzodiazepines which act at the same receptor targets as benzodiazepines but have distinct chemical structures.

    Tracazolate has primarily anxiolytic and anticonvulsant effects, with sedative and muscle relaxant effects only appearing at higher doses. It has a unique receptor binding profile involving allosteric modulation of several GABAA receptor subtypes, being selective for GABAA receptors containing α1 and β3 subunits, but exhibiting different effects depending on the third type of subunit making up the receptor complex.

    See also


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