Abafungin

Abafungin

Clinical data
Trade names	Abasol
Routes of administration	Topical (cream)
ATC code	none
Identifiers
IUPAC name N-[4-[2-(2,4-dimethylphenoxy)phenyl]-1,3-thiazol-2-yl]-1,4,5,6-tetrahydropyrimidin-2-amine
CAS Number	129639-79-8 N
PubChem CID	159326
DrugBank	DB06395 Y
ChemSpider	140124 Y
UNII	11DI31LWXF
ChEBI	CHEBI:76005 N
ECHA InfoCard	100.125.129
Chemical and physical data
Formula	C21H22N4OS
Molar mass	378.49 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1=CC(=C(C=C1)OC2=CC=CC=C2C3=CSC(=N3)NC4=NCCCN4)C
InChI InChI=1S/C21H22N4OS/c1-14-8-9-18(15(2)12-14)26-19-7-4-3-6-16(19)17-13-27-21(24-17)25-20-22-10-5-11-23-20/h3-4,6-9,12-13H,5,10-11H2,1-2H3,(H2,22,23,24,25) Y Key:TYBHXIFFPVFXQW-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Abafungin (INN) is a broad-spectrum antifungal agent with a novel mechanism of action for the treatment of dermatomycoses.

Abasol is a topical cream formulation of abafungin by York Pharma.

History

Abafungin was first synthesized at Bayer AG, Leverkusen, Germany. A study of H₂-antagonists related to famotidine, resulted in the discovery of its antifungal properties.

Its development seems to have been discontinued in 2009.

Mechanism of action

Unlike imidazole- and triazole-class antifungals, abafungin directly impairs the fungal cell membrane.

In addition, abafungin inhibits the enzyme sterol 24-C-methyltransferase, modifying the composition of the fungal membrane.

Abafungin has antibiotic activity against gram-positive bacteria as well as sporicidal activity.

External links

• Media related to Abafungin at Wikimedia Commons