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Abandoned drugs
Algestone
Другие языки:

Algestone

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Algestone
Algestone.svg
Clinical data
Other names Dihydroxyprogesterone; DHP; Alfasone; Alphasone; Neo-Alfasol; 16α,17α-Dihydroxyprogesterone; 16α,17α-Dihydroxypregn-4-ene-3,20-dione; Alphasone; Alfasone
Drug class Progestin; Progestogen
ATC code
  • None
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • (8R,9S,10R,13S,14S,16R,17S)-17-acetyl-16,17-dihydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
CompTox Dashboard (EPA)
ECHA InfoCard 100.008.974
Chemical and physical data
Formula C21H30O4
Molar mass 346.467 g·mol−1
3D model (JSmol)
  • O=C4\C=C2/[C@]([C@H]1CC[C@@]3([C@@](O)(C(=O)C)[C@H](O)C[C@H]3[C@@H]1CC2)C)(C)CC4
  • InChI=1S/C21H30O4/c1-12(22)21(25)18(24)11-17-15-5-4-13-10-14(23)6-8-19(13,2)16(15)7-9-20(17,21)3/h10,15-18,24-25H,4-9,11H2,1-3H3/t15-,16+,17+,18-,19+,20+,21-/m1/s1
  • Key:CXDWHYOBSJTRJU-SRWWVFQWSA-N

Algestone (INN), also known as alphasone or alfasone, as well as dihydroxyprogesterone, is a progestin which was never marketed. Another progestin, algestone acetophenide, in contrast, has been marketed as a hormonal contraceptive.

Chemistry

See also: List of progestogens

Algestone, also known as 16α,17α-dihydroxyprogesterone or as 16α,17α-dihydroxypregn-4-ene-3,20-dione, is a synthetic pregnane steroid and a derivative of progesterone and 17α-hydroxyprogesterone. Closely related analogues of algestone include 16α-hydroxyprogesterone, algestone acetonide, and algestone acetophenide.



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