Androgen-dependent condition
An androgen-dependent condition, disease, disorder, or syndrome, is a medical condition that is, in part or full, dependent on, or is sensitive to, the presence of androgenic activity in the body.
Known androgen-dependent conditions include acne,seborrhea,androgenic alopecia,hirsutism,hidradenitis suppurativa,precocious puberty in boys,hypersexuality,paraphilias,benign prostatic hyperplasia (BPH),prostate cancer, and hyperandrogenism in women such as in polycystic ovary syndrome (PCOS), congenital adrenal hyperplasia (CAH), and androgen-secreting tumors (gonadal or adrenal tumor).
Such conditions may be treated with drugs with antiandrogen actions, including androgen receptor antagonists such as cyproterone acetate, spironolactone, and bicalutamide, 5α-reductase inhibitors such as finasteride and dutasteride, CYP17A1 inhibitors such as abiraterone acetate, gonadotropin-releasing hormone (GnRH) analogues such as leuprorelin and cetrorelix, and/or other antigonadotropins such as megestrol acetate and medroxyprogesterone acetate.
See also
- Androgen deprivation therapy
- Androgen insensitivity syndrome
- Estrogen-dependent condition
- Spinal bulbar muscular atrophy
Further reading
- Shukla, G. C.; Plaga, A. R.; Shankar, E.; Gupta, S. (2016). "Androgen receptor-related diseases: what do we know?". Andrology. 4 (3): 366–381. doi:10.1111/andr.12167. ISSN 2047-2919. PMID 26991422.