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Attributable fraction among the exposed
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    Attributable fraction among the exposed

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    In epidemiology, attributable fraction among the exposed (AFe) is the proportion of incidents in the exposed group that are attributable to the risk factor. The term attributable risk percent among the exposed is used if the fraction is expressed as a percentage. It is calculated as , where is the incidence in the exposed group, is the incidence in the unexposed group, and is the relative risk.

    Illustration of two groups: one exposed to a risk factor, and one unexposed. Exposed group has larger risk of adverse outcome (AFe = 1/3).
    Group exposed to a risk factor (left) has increased risk of an adverse outcome (black) compared to the unexposed group (right). In the exposed group, one third of the adverse outcomes can be attributed to the exposure (AFe = 1/3).

    It is used when an exposure increases the risk, as opposed to reducing it, in which case its symmetrical notion is preventable fraction among the unexposed.

    Synonyms

    Multiple synonyms of AFe are in use: attributable fraction, relative attributable risk, attributable proportion among the exposed, and attributable risk among the exposed.

    Similarly, attributable risk percent (ARP) is used as a synonym for the attributable risk percent among the exposed.

    In climatology, fraction of attributable risk (FAR) is used to denote a proportion of adverse event risk attributable to the human influence on climate or other forcing factor.

    Numerical example

    Example of risk increase
    Quantity Experimental group (E) Control group (C) Total
    Events (E) EE = 75 CE = 100 175
    Non-events (N) EN = 75 CN = 150 225
    Total subjects (S) ES = EE + EN = 150 CS = CE + CN = 250 400
    Event rate (ER) EER = EE / ES = 0.5, or 50% CER = CE / CS = 0.4, or 40%
    Variable Abbr. Formula Value
    Absolute risk increase ARI EERCER 0.1, or 10%
    Number needed to harm NNH 1 / (EERCER) 10
    Relative risk (risk ratio) RR EER / CER 1.25
    Relative risk increase RRI (EERCER) / CER, or RR − 1 0.25, or 25%
    Attributable fraction among the exposed AFe (EERCER) / EER 0.2
    Odds ratio OR (EE / EN) / (CE / CN) 1.5

    See also


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