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Chlorphenesin carbamate

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Chlorphenesin carbamate
Chlorphenesin.svg
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
ATC code
Pharmacokinetic data
Excretion urine
Identifiers
  • (3-(4-chlorophenoxy)-2-hydroxypropyl)carbamate
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.002.902
Chemical and physical data
Formula C10H12ClNO4
Molar mass 245.66 g·mol−1
3D model (JSmol)
Melting point 86 to 92 °C (187 to 198 °F)
  • c1cc(ccc1OCC(COC(=O)N)O)Cl
  • InChI=1S/C10H12ClNO4/c11-7-1-3-9(4-2-7)15-5-8(13)6-16-10(12)14/h1-4,8,13H,5-6H2,(H2,12,14)
  • Key:SKPLBLUECSEIFO-UHFFFAOYSA-N

Chlorphenesin carbamate (Maolate, Musil) is a centrally acting muscle relaxant used to treat muscle pain and spasms. Chlorphenesin carbamate is no longer used for this purpose in most developed nations due to the availability of much safer spasmolytics such as benzodiazepines.

Other central effects include sedation, anxiolysis, and dizziness.

Chlorphenesin

A related chemical, chlorphenesin (C9H11ClO3) without the carbamate group, is used as a preservative in products such as cosmetics. It has antifungal and some antibacterial properties, and is classified as an antifungal for topical use by the WHO.

The major adverse effect from this preservative on skin is allergic contact sensitivity. Systemic intoxication from transdermal use has not been observed, although the FDA discourages its use as an ingredient in nipple cream for nursing mothers.

See also


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