Dexchlorpheniramine

Dexchlorpheniramine

Clinical data
Trade names	Chlor-trimeton, Polaramine
AHFS/Drugs.com	Monograph
MedlinePlus	a682543
Routes of administration	Oral, Intravenous
ATC code	R06AB02 (WHO)
Legal status
Legal status	AU: S3 (Pharmacist only)
Identifiers
IUPAC name (3S)-3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-3-ylpropan-1-amine
CAS Number	25523-97-1 Y
PubChem CID	33036
IUPHAR/BPS	1210
DrugBank	DB01114 Y
ChemSpider	30576 Y
UNII	3Q9Q0B929N
KEGG	D07803 Y
ChEBI	CHEBI:4464 Y
ChEMBL	ChEMBL1201353 Y
CompTox Dashboard (EPA)	DTXSID50180225
ECHA InfoCard	100.042.779
Chemical and physical data
Formula	C16H19ClN2
Molar mass	274.79 g·mol−1
3D model (JSmol)	Interactive image
SMILES Clc1ccc(cc1)[C@@H](c2ncccc2)CCN(C)C
InChI InChI=1S/C16H19ClN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3/t15-/m0/s1 Y Key:SOYKEARSMXGVTM-HNNXBMFYSA-N Y
(verify)

Dexchlorpheniramine (trade name Polaramine) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. It is the pharmacologically active dextrorotatory isomer of chlorpheniramine.

It came into medical use in 1959 and was patented in 1962.

Pharmacology

Dexchlorpheniramine is an antihistamine, or an antagonist of the histamine H₁ receptor. A study found that dexchlorpheniramine had a K_i value of 20 to 30 μM for the muscarinic acetylcholine receptors using rat brain tissue.

External links

• Polaramine consumer information
• Polaramine (dexchlorpheniramine) medical facts