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Monoamine oxidase inhibitor
Difenamizole
Другие языки:

Difenamizole

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Difenamizole
Difenamizole.svg
Names
IUPAC name
2-(Dimethylamino)-N-(2,5-diphenylpyrazol-3-yl)propanamide
Other names
Diphenamizole
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
PubChem CID
UNII
  • InChI=1S/C20H22N4O/c1-15(23(2)3)20(25)21-19-14-18(16-10-6-4-7-11-16)22-24(19)17-12-8-5-9-13-17/h4-15H,1-3H3,(H,21,25)
    Key: PCXMKBOWWVXEDT-UHFFFAOYSA-N
  • CC(C(=O)NC1=CC(=NN1C2=CC=CC=C2)C3=CC=CC=C3)N(C)C
Properties
C20H22N4O
Molar mass 334.423 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Difenamizole (INN; brand name Pasalin; former developmental code name AP-14) is a nonsteroidal anti-inflammatory drug (NSAID) and analgesic of the pyrazolone group related to metamizole. It has monoaminergic properties, including inhibition of monoamine oxidase, augmentation of pargyline-induced elevation of striatal dopamine levels, inhibition of K+-induced striatal dopamine release, and inhibition of the reuptake of dopamine.

See also



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