Epinastine

Epinastine

Clinical data
Trade names	Alesion, Elestat, Purivist, Relestat
AHFS/Drugs.com	Monograph
MedlinePlus	a604011
Pregnancy category	C
Routes of administration	Eye drops
ATC code	R06AX24 (WHO) S01GX10 (WHO)
Pharmacokinetic data
Protein binding	64%
Elimination half-life	12 hours
Identifiers
IUPAC name (RS)-3-amino-9,13b-dihydro-1H-dibenz(c,f)imidazo(1,5-a)azepine
CAS Number	80012-43-7 Y
PubChem CID	3241
IUPHAR/BPS	7176
DrugBank	DB00751 Y
ChemSpider	3128 Y
UNII	Q13WX941EF
KEGG	D07900 Y
ChEBI	CHEBI:51032 Y
ChEMBL	ChEMBL1106 Y
CompTox Dashboard (EPA)	DTXSID2048371
ECHA InfoCard	100.120.187
Chemical and physical data
Formula	C16H15N3
Molar mass	249.317 g·mol−1
3D model (JSmol)	Interactive image
SMILES N\4=C(\N3c1c(cccc1)Cc2c(cccc2)C3C/4)N
InChI InChI=1S/C16H15N3/c17-16-18-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)19(15)16/h1-8,15H,9-10H2,(H2,17,18) Y Key:WHWZLSFABNNENI-UHFFFAOYSA-N Y
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Epinastine (brand names Alesion, Elestat, Purivist, Relestat) is a second-generation antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis. It is produced by Allergan and marketed by Inspire in the United States. It is highly selective for the H₁ receptor and does not cross the blood-brain-barrier.

It was patented in 1980 and came into medical use in 1994.

External links

• Official U.S. website of Elestat