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Abandoned drugs
Estradiol 17β-tetrahydropyranyl ether
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    Estradiol 17β-tetrahydropyranyl ether

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    Estradiol 17β-tetrahydropyranyl ether
    Estradiol 17β-tetrahydropyranyl ether.svg
    Clinical data
    Other names RS-2290; NSC-99694; Estra-1,3,5(10)-triene-17β-diol 17β-(tetrahydropyran-2-yl) ether; 17β-(Tetrahydro-2H-pyran-2-yloxy)estra-1,3,5(10)-trien-3-ol
    Routes of
    administration    		 By mouth
    Drug class Estrogen; Estrogen ether
    Identifiers
    • (8R,9S,13S,14S,17S)-13-methyl-17-(oxan-2-yloxy)-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-ol
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    Chemical and physical data
    Formula C23H32O3
    Molar mass 356.506 g·mol−1
    3D model (JSmol)
    • C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2OC4CCCCO4)CCC5=C3C=CC(=C5)O
    • InChI=1S/C23H32O3/c1-23-12-11-18-17-8-6-16(24)14-15(17)5-7-19(18)20(23)9-10-21(23)26-22-4-2-3-13-25-22/h6,8,14,18-22,24H,2-5,7,9-13H2,1H3/t18-,19-,20+,21+,22?,23+/m1/s1
    • Key:DRRJWMXJIVWKKW-CUFSGNDSSA-N

    Estradiol 17β-tetrahydropyranyl ether is a synthetic estrogen and estrogen ether which was never marketed. It has been reported to possess improved oral activity relative to estradiol. One study in animals found that it had 15 times the oral activity of estradiol.

    See also




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