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Estradiol undecylenate
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    Estradiol undecylenate

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    Estradiol undecylenate
    Estradiol undecylenate.svg
    Clinical data
    Other names SH-368; Estradiol undecenoate; Estra-1,3,5(10)-triene-3,17β-diol 17β-(10-undecenoate)
    Routes of
    administration
    Intramuscular injection
    Drug class Estrogen; Estrogen ester
    Identifiers
    • [(8R,9S,13S,14S,17S)-3-Hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] undec-10-enoate
    CAS Number
    PubChem CID
    ChemSpider
    CompTox Dashboard (EPA)
    ECHA InfoCard 100.080.203
    Chemical and physical data
    Formula C29H42O3
    Molar mass 438.652 g·mol−1
    3D model (JSmol)
    • C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2OC(=O)CCCCCCCCC=C)CCC4=C3C=CC(=C4)O
    • InChI=1S/C29H42O3/c1-3-4-5-6-7-8-9-10-11-28(31)32-27-17-16-26-25-14-12-21-20-22(30)13-15-23(21)24(25)18-19-29(26,27)2/h3,13,15,20,24-27,30H,1,4-12,14,16-19H2,2H3/t24-,25-,26+,27+,29+/m1/s1
    • Key:VJTIEHBTPQORML-GVGNIZHQSA-N

    Estradiol undecylenate (EUe; developmental code name SH-368) is an estrogen medication and estrogen ester which was never marketed. It is the C17β undecenoate (undecylenate) ester of estradiol. Following an intramuscular injection, EUe has a very prolonged effect, exceeding that of other estradiol esters like estradiol valerate and estradiol enanthate. Due to its very long duration of action, EUe releases only subthreshold amounts of estradiol at conventional doses. However, this may still be useful in menopausal hormone therapy.

    See also



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