Fludiazepam

Fludiazepam

Clinical data
Trade names	Erispan (JP, TW)
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral (tablets)
ATC code	N05BA17 (WHO)
Legal status
Legal status	CA: Schedule IV DE: Anlage III (Special prescription form required) US: Schedule IV
Pharmacokinetic data
Metabolism	Hepatic
Excretion	Renal
Identifiers
IUPAC name 7-chloro-5-(2-fluorophenyl)-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
CAS Number	3900-31-0 Y
PubChem CID	3369
DrugBank	DB01567 Y
ChemSpider	3252 Y
UNII	7F64A2K16Z
KEGG	D01354 Y
ChEBI	CHEBI:31618 Y
ChEMBL	ChEMBL13291 Y
CompTox Dashboard (EPA)	DTXSID00192277
ECHA InfoCard	100.292.343
Chemical and physical data
Formula	C16H12ClFN2O
Molar mass	302.7 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C1CN=C(C2=CC=CC=C2F)C3=CC(Cl)=CC=C3N1C
InChI InChI=1S/C16H12ClFN2O/c1-20-14-7-6-10(17)8-12(14)16(19-9-15(20)21)11-4-2-3-5-13(11)18/h2-8H,9H2,1H3 Y Key:ROYOYTLGDLIGBX-UHFFFAOYSA-N Y
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Fludiazepam, marketed under the brand name Erispan (エリスパン) is a potent benzodiazepine and 2ʹ-fluoro derivative of diazepam, originally developed by Hoffman-La Roche in the 1960s. It is marketed in Japan and Taiwan. It exerts its pharmacological properties via enhancement of GABAergic inhibition. Fludiazepam has 4 times more binding affinity for benzodiazepine receptors than diazepam. It possesses anxiolytic,anticonvulsant, sedative, hypnotic and skeletal muscle relaxant properties. Fludiazepam has been used recreationally.

See also

• Diazepam
• Diclazepam (the 2ʹ-chloro analog)
• Difludiazepam (the 2',6'-difluoro derivative)
• Flunitrazepam (the 7-nitro analog)
• Flualprazolam (the triazolo derivative)
• Ro20-8552

External links

• "エリスパンフルジアゼパム錠0.25mg，細粒0.1% Erispan (fludiazepam tablets 0.25 mg, fine granules 0.1%) Prescribing Information" (in Japanese). Sumitomo Dainippon Pharma.
• (in Japanese) Official Dainippon Sumitomo Pharma Website