Fluoroestradiol F-18

Fluoroestradiol F-18

Clinical data
Trade names	Cerianna
Other names	[18F]16α-Fluoroestradiol; [18F]16α-Fluoroestra-1,3,5(10)-triene-3,17β-diol
License data	US DailyMed: Fluoroestradiol
Routes of administration	Intravenous injection
Drug class	Estrogen; Diagnostic radiopharmaceutical
ATC code	V09IX11 (WHO)
Legal status
Legal status	US: ℞-only
Pharmacokinetic data
Metabolism	Liver
Excretion	Gallbladder and kidney
Identifiers
IUPAC name (8R,9S,13S,14S,16R,17R)-16-(18F)fluoranyl-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
CAS Number	94153-53-4
PubChem CID	10869981
ChemSpider	9045262
UNII	T32277KB09
KEGG	D11829
Chemical and physical data
Formula	C18H23[18F]O2
Molar mass	289.37
3D model (JSmol)	Interactive image
SMILES CC12CCC3C(C1CC(C2O)[18F])CCC4=C3C=CC(=C4)O
InChI InChI=1S/C18H23FO2/c1-18-7-6-13-12-5-3-11(20)8-10(12)2-4-14(13)15(18)9-16(19)17(18)21/h3,5,8,13-17,20-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1/i19-1 Key:KDLLNMRYZGUVMA-ZYMZXAKXSA-N

Fluoroestradiol F-18, also known as [¹⁸F]16α-fluoroestradiol and sold under the brand name Cerianna, is a radioactive diagnostic agent indicated for use with positron emission tomography (PET) imaging. It is an analog of estrogen and is used to detect estrogen receptor-positive breast cancer lesions.

Chemistry

Chemically, fluoroestradiol F-18 is [¹⁸F]16α-fluoro-3,17β-diol-estratriene-1,3,5(10).

History

Fluoroestradiol F-18 was approved for medical use in the United States in May 2020.

See also

• 4-Fluoroestradiol

External links

• "Fluoroestradiol F-18". Drug Information Portal. U.S. National Library of Medicine.
• "Fluoroestradiol F-18". NCI Thesaurus. 4 May 2020.