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Antiinfective agent stubs
Fosfluconazole
Другие языки:

Fosfluconazole

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Fosfluconazole
Fosfluconazol.svg
Clinical data
AHFS/Drugs.com International Drug Names
Routes of
administration		 IV
ATC code
  • none
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • {[2-(2,4-Difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-yl]oxy}phosphonic acid
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
Formula C13H13F2N6O4P
Molar mass 386.256 g·mol−1
3D model (JSmol)
  • Fc1ccc(c(F)c1)C(OP(=O)(O)O)(Cn2ncnc2)Cn3ncnc3
  • InChI=1S/C13H13F2N6O4P/c14-10-1-2-11(12(15)3-10)13(25-26(22,23)24,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9H,4-5H2,(H2,22,23,24) checkY
  • Key:GHJWNRRCRIGGIO-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Fosfluconazole (INN) is a water-soluble phosphate prodrug of fluconazole — a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.

The phosphate ester bond is hydrolyzed by the action of a phosphatase — an enzyme that removes a phosphate group from its substrate by hydrolyzing phosphoric acid monoesters into a phosphate ion and a molecule with a free hydroxyl group (dephosphorylation).


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