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Abandoned drugs
Gestadienol acetate
Другие языки:

    Gestadienol acetate

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    Gestadienol acetate
    Gestadienol acetate.svg
    Clinical data
    Other names CIBA-31458-Ba; CIBA-31458; Norhydroxy-δ6-progesterone acetate; 6-Dehydro-17α-acetoxy-19-norprogesterone; 17α-Acetoxy-19-norpregn-4,6-diene-3,20-dione
    Routes of
    administration    		 By mouth
    Drug class Progestogen; Progestogen ester
    Identifiers
    • [(8R,9S,10R,13S,14S,17R)-17-acetyl-13-methyl-3-oxo-1,2,8,9,10,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate
    CAS Number
    PubChem CID
    ECHA InfoCard 100.224.529
    Chemical and physical data
    Formula C22H28O4
    Molar mass 356.462 g·mol−1
    3D model (JSmol)
    • CC(=O)[C@]1(CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2C=CC4=CC(=O)CC[C@H]34)C)OC(=O)C
    • InChI=1S/C22H28O4/c1-13(23)22(26-14(2)24)11-9-20-19-6-4-15-12-16(25)5-7-17(15)18(19)8-10-21(20,22)3/h4,6,12,17-20H,5,7-11H2,1-3H3/t17-,18+,19+,20-,21-,22-/m0/s1
    • Key:TUFRQQROGGMVOC-ZCPXKWAGSA-N

    Gestadienol acetate (developmental code name CIBA-31458-Ba or CIBA-31458) an orally active progestin which was described in the literature in 1967 and was never marketed. It has no androgenic or estrogenic effects. The effects of gestadienol acetate on the endometrium and its general pharmacology were studied in a clinical trial in women. It has also been studied in a clinical trial for benign prostatic hyperplasia in men, but was ineffective.

    Chemistry

    See also: List of progestogens, List of progestogen esters, and Progestogen ester

    Gestadienol acetate, also known as norhydroxy-δ6-progesterone acetate, 6-dehydro-17α-hydroxy-19-norprogesterone 17α-acetate, or 17α-hydroxy-19-norpregn-4,6-diene-3,20-dione 17α-acetate, is a synthetic norpregnane steroid and a derivative of progesterone. It is specifically a combined derivative of 17α-hydroxyprogesterone and 19-norprogesterone, or of gestronol (17α-hydroxy-19-norprogesterone), with an acetate ester at the C17α position and a double bond between the C6 and C7 positions. Gestadienol acetate is the C17α acetate ester of gestadienol.Analogues of gestadienol acetate include algestone acetophenide (dihydroxyprogesterone acetophenide), demegestone, gestonorone caproate (norhydroxyprogesterone caproate), hydroxyprogesterone acetate, hydroxyprogesterone caproate, nomegestrol acetate, norgestomet, and segesterone acetate (nestorone).




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