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Drugs with unknown mechanisms of action
Glufimet
Другие языки:

    Glufimet

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    Glufimet
    Glufimet.svg
    Clinical data
    Other names RGPU-238; Dimethyl 3-phenylglutamic acid hydrochloride; Dimethyl 3-phenylglutamate hydrochloride; 1,5-Dimethyl (2S)-2-amino-3-phenylpentanedioate hydrochloride
    Identifiers
    • dimethyl 2-amino-3-phenylpentanedioate;hydrochloride
    CAS Number
    PubChem CID
    ChemSpider
    CompTox Dashboard (EPA)
    Chemical and physical data
    Formula C13H18ClNO4
    Molar mass 287.74 g·mol−1
    3D model (JSmol)
    • COC(=O)CC(C1=CC=CC=C1)C(C(=O)OC)N.Cl
    • InChI=1S/C13H17NO4.ClH/c1-17-11(15)8-10(12(14)13(16)18-2)9-6-4-3-5-7-9;/h3-7,10,12H,8,14H2,1-2H3;1H
    • Key:YYGZEJCVUMTAMY-UHFFFAOYSA-N

    Glufimet (developmental code name RGPU-238), also known as dimethyl 3-phenylglutamate hydrochloride, is a derivative of glutamic acid (glutamate) which was developed in Russia and is related to the γ-aminobutyric acid (GABA) derivative phenibut (3-phenyl-GABA). It contains phenibut and glycine fragments in its chemical structure, has been described as a "GABA precursor", and is said to modulate the GABA and nitric oxide (NO) systems and to have antioxidant activity. It has been suggested that metabotropic glutamate receptors may also play a role in the mechanism of action of glufimet.Stress-protective effects have been described for glufimet in animals.




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