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Pharmacology stubs
HPTE
Другие языки:

HPTE

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HPTE
2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane.svg
Names
Preferred IUPAC name
4,4′-(2,2,2-Trichloroethane-1,1-diyl)diphenol
Other names
p,p'-Hydroxy-DDT
Hydroxychlor
2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane
1,1,1-Trichloro-2,2-bis(4-hydroxyphenyl)ethane
Identifiers
3D model (JSmol)
2054671
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.152.496
EC Number
  • 623-854-1
KEGG
PubChem CID
UNII
  • InChI=1S/C14H11Cl3O2/c15-14(16,17)13(9-1-5-11(18)6-2-9)10-3-7-12(19)8-4-10/h1-8,13,18-19H
    Key: IUGDILGOLSSKNE-UHFFFAOYSA-N
  • InChI=1S/C14H11Cl3O2/c15-14(16,17)13(9-1-5-11(18)6-2-9)10-3-7-12(19)8-4-10/h1-8,13,18-19H
    Key: IUGDILGOLSSKNE-UHFFFAOYSA-N
  • C1=CC(=CC=C1C(C2=CC=C(C=C2)O)C(Cl)(Cl)Cl)O
Properties
C14H11Cl3O2
Molar mass 317.59 g·mol−1
Hazards
GHS labelling:
GHS07: Exclamation mark
Warning
H315, H319, H335
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

HPTE, also known as hydroxychlor, p,p'-hydroxy-DDT, or 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane, is a metabolite of methoxychlor, a synthetic insecticide related to DDT. Like bisphenol A with similar chemical structure, HPTE is an endocrine disruptor which has estrogenic activity, and also inhibits Cholesterol side-chain cleavage enzyme (P450scc, CYP11A1) and 3α-hydroxysteroid dehydrogenase (3α-HSD).



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