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List of investigational analgesics
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This is a list of investigational analgesics, or analgesics that are currently under development for clinical use but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses.
Opioid receptor modulators
- Axelopran/oxycodone – combination of a centrally active μ-opioid receptor agonist and a peripherally selective μ-, κ-, and δ-opioid receptor antagonist.
- Cebranopadol (GRT-6005) – non-selective μ-opioid receptor, nociceptin receptor, and δ-opioid receptor full agonist and κ-opioid receptor partial agonist
- Desmetramadol (O-desmethyltramadol; Omnitram) – μ-opioid receptor agonist, norepinephrine reuptake inhibitor (NRI), and 5-HT2C receptor antagonist.
- Lexanopadol (GRT-6006, GRT13106G) – non-selective opioid receptor agonist
- Oxycodone/naltrexone – combination of a μ-opioid receptor agonist and a μ- and κ-opioid receptor antagonist.
Sodium channel blockers
- BIIB-095 – state-dependent and use-dependent Nav blocker, including Nav1.7.
- CC-8464 (ASP-1807) – selective Nav1.7 blocker
- Cenobamate (YKP-3089) – atypical voltage-gated sodium channel blocker.
- DSP-2230 – selective Nav1.7 and Nav1.8 blocker.
- Funapide (TV-45070, XEN402) – selective Nav1.7 and Nav1.8 blocker.
- GDC-0276 (RG-7893) – selective Nav1.7 blocker [1]
- GDC-0310 (RG-6029) – selective Nav1.7 blocker [2]
- NKTR-171 – voltage-gated sodium channel blocker [3]
- PF-05089771 – selective Nav1.7 and Nav1.8 blocker [4]
- Ralfinamide (NW-1029) – non-selective voltage-gated sodium channel blocker, as well as other actions [5]
- Tetrodotoxin (9401-TTX; Tectin, Tetrodin, Tocudin) – non-selective voltage-gated sodium channel blocker [6]
- Vixotrigine (formerly raxatrigine; CNV1014802, GSK-1014802, BIIB 074) – non-selective voltage-gated sodium channel blocker [7]
- VX-150 – selective Nav1.8 blocker [8]
- VX-548 – selective Nav1.8 blocker
Calcium channel blockers
TRP channel modulators
- Capsaicin (Adlea, ALGRX-4975, CNTX-4975, VLNX-4975) – TRPV1 agonist [10]
- Capsaicin/diclofenac – combination of a TRPV1 agonist and a COX-2 inhibitor for topical application [11]
- CMX-020 – TRPV1 modulator as well as CB1 and CB2 receptor modulator [12]
- DWP-05195 (TR-1) – TRPV1 antagonist [13]
- GRC-6211 – TRPV1 agonist [14]
- JNJ-38893777 – TRPV1 antagonist [15]
- Mavatrep (JNJ‐39439335) – TRPV1 antagonist.
- NEO-6860 – TRPV1 antagonist [16]
- Parentide (DD-04107) – TRPV1 antagonist [17]
- Resiniferatoxin (RTX; MCP-101) – TRPV1 agonist [18]
- SAR-115740 – TRPV1 antagonist [19]
- Tivanisiran (SYL-1001) – TRPV1 antagonist [20]
Cannabinoid receptor modulators
- ABX-1431 – selective monoacylglycerol lipase inhibitor[21]
- Cannabidiol (CBD) – cannabinoid receptor modulator [22][23]
- Cannabidivarin (CBDV; GWP-42006) – cannabinoid receptor modulator [24]
- CMX-020 – TRPV1 modulator as well as CB1 and CB2 receptor modulator [25]
- Dronabinol (Δ9-THC; ECP022A, Namisol) – CB1 and CB2 receptor agonist [26][27]
- Nabilone – CB1 and CB2 receptor agonist [28]
- NEO-1940 – CB1 and CB2 receptor agonist [29]
- Olorinab (APD-371) – CB2 receptor agonist [30]
Nerve growth factor inhibitors
- Fasinumab (REGN-475, SAR-164877) – monoclonal antibody against nerve growth factor[31]
- Fulranumab (AMG-403, JNJ-42160443) – monoclonal antibody against nerve growth factor [32]
- GBR-900 – monoclonal antibody against TrkA[33]
- GZ-389988 – TrkA, TrkB, and TrkC kinase inhibitor[34]
- LEVI-04 (p75NTR-Fc) – LNGF receptor (p75NTR) fusion protein and decoy receptor for nerve growth factor [35]
- NRD135S-E1 – tyrosine kinase modulator[36][37]
- ONO-4474 – peripherally selective TrkA, TrkB, and TrkC kinase inhibitor[38]
- Ranevetmab (NV-01) – monoclonal antibody against nerve growth factor for dogs [39]
- Tanezumab (PF-4383119, RI-624, RN-624) – monoclonal antibody against nerve growth factor [40]
- VM-902A – selective, peripherally selective allosteric inhibitor of TrkA [41]
Others
- ALLOD-2 – undefined mechanism of action [42]
- CR-4056 – imidazoline I2 receptor agonist [43]
- E-52862 (MR-309; S1A; S1RA) – sigma-1 receptor antagonist [44]
- HSP-3150 – undefined mechanism of action [45]
- KCP-506 – nicotinic acetylcholine receptor antagonist [46]
- LATER – CRISPR-dCas9 gene-editing
- PAX-01 – undefined mechanism of action [47]
See also
External links
Monoaminergics |
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Ion channel blockers |
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Others |
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