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Antidepressant
Litoxetine
Другие языки:

Litoxetine

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Litoxetine
Litoxetine-2D-skeletal.png
Clinical data
Other names SL 81-0385; IXA-001
ATC code
  • None
Identifiers
  • 4-(naphthalen-2-ylmethoxy)piperidine
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
Formula C16H19NO
Molar mass 241.334 g·mol−1
3D model (JSmol)
  • C3CNCCC3OCc2cc1ccccc1cc2

Litoxetine (developmental code names SL 81-0385, IXA-001) is an antidepressant which was under clinical development for the treatment of depression in the early 1990s but was never marketed. It acts as a potent serotonin reuptake inhibitor (Ki for SERT = 7 nM) and modest 5-HT3 receptor antagonist (Ki = 315 nM). It has antiemetic activity, and unlike the selective serotonin reuptake inhibitors (SSRIs), appears to have a negligible incidence of nausea and vomiting. The drug is structurally related to indalpine. Development of litoxetine for depression was apparently ceased in the late 1990s. However, as of March 2017, development of litoxetine has been reinitiated and the drug is now in the phase II stage for the treatment of urinary incontinence.

External links

  • "Litoxetine". Drug Information Portal. U.S. National Library of Medicine.

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