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Methdilazine

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Methdilazine
Methdilazine.svg
Clinical data
AHFS/Drugs.com Monograph
ATC code
Identifiers
  • 10-[(1-methylpyrrolidin-3-yl) methyl]- 10H-phenothiazine
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.016.220
Chemical and physical data
Formula C18H20N2S
Molar mass 296.43 g·mol−1
3D model (JSmol)
  • S2c1ccccc1N(c3c2cccc3)CC4CCN(C)C4
  • InChI=1S/C18H20N2S/c1-19-11-10-14(12-19)13-20-15-6-2-4-8-17(15)21-18-9-5-3-7-16(18)20/h2-9,14H,10-13H2,1H3 checkY
  • Key:HTMIBDQKFHUPSX-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Methdilazine (Dilosyn, Tacaryl) is a first-generation antihistamine with anticholinergic properties of the phenothiazine class.

Synthesis

Methdilazine synthesis: R. F. Feldkamp and Y. H. Wu; Mead Johnson & Company; U.S. Patent 2,945,855 (1960).

See also

The ring-contracted analog, methdilazine shows only very weak activity as a tranquilizer; instead, that agent constitutes an important antihistamine.



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