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Antidepressant
MRK-016
Другие языки:

    MRK-016

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    MRK-016
    MRK-016.svg
    Names
    Preferred IUPAC name
    3-tert-Butyl-7-(5-methyl-1,2-oxazol-3-yl)-2-[(1H-1,2,4-triazol-5-yl)methoxy]pyrazolo[1,5-d][1,2,4]triazine
    Identifiers
    3D model (JSmol)
    ChemSpider
    PubChem CID
    UNII
    • InChI=1S/C17H20N8O2/c1-10-6-11(23-27-10)15-21-19-7-12-14(17(2,3)4)16(22-25(12)15)26-8-13-18-9-20-24(13)5/h6-7,9H,8H2,1-5H3
      Key: QYSYOGCIDRANAR-UHFFFAOYSA-N
    • CN1N=CN=C1COC1=NN2C(C=NN=C2C2=NOC(C)=C2)=C1C(C)(C)C
    Properties
    C17H20N8O2
    Molar mass 368.401 g·mol−1
    Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

    MRK-016 is a selective α5 subunit-containing GABAA negative allosteric modulator, that has nootropic properties. It has been found to produce rapid, ketamine-like antidepressant effects in animal models of depression.

    See also


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