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Abandoned drugs
RH-34
Другие языки:

    RH-34

    Подписчиков: 0, рейтинг: 0
    RH-34
    RH-34 structure.png
    Clinical data
    Routes of
    administration    		 ?
    ATC code
    • none
    Legal status
    Legal status
    • In general: uncontrolled
    Identifiers
    • 3-[2-(2-methoxybenzylamino)ethyl]-1H-quinazoline-2,4-dione
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    CompTox Dashboard (EPA)
    Chemical and physical data
    Formula C18H19N3O3
    Molar mass 325.368 g·mol−1
    3D model (JSmol)
    • O=C1C=2C(NC(=O)N1CCNCC3=C(OC)C=CC=C3)=CC=CC2
    • InChI=1S/C18H19N3O3/c1-24-16-9-5-2-6-13(16)12-19-10-11-21-17(22)14-7-3-4-8-15(14)20-18(21)23/h2-9,19H,10-12H2,1H3,(H,20,23) ☒N
    • Key:NUAJBITWGGTZCM-UHFFFAOYSA-N ☒N
     ☒NcheckY (what is this?)  (verify)

    RH-34 is a compound which acts as a potent and selective partial agonist for the 5-HT2A serotonin receptor subtype. It was derived by structural modification of the selective 5-HT2Aantagonist ketanserin, with the 4-(p-fluorobenzoyl)piperidine moiety replaced by the N-(2-methoxybenzyl) pharmacophore found in such potent 5-HT2A agonists as NBOMe-2C-B and NBOMe-2C-I. This alteration was found to retain 5-HT2Aaffinity and selectivity, but reversed activity from an antagonist to a moderate efficacy partial agonist.

    Legal status

    RH-34 is a controlled substance in Hungary and Brazil.

    See also


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