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Abandoned drugs
Serazapine
Другие языки:

Serazapine

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Serazapine
Serazapine Structure.svg
Clinical data
Other names CGS-15040A
Routes of
administration		 By mouth
ATC code
  • None
Identifiers
  • methyl 2-methyl-1,3,4,16b-tetrahydro-2H,10H-benzo[5,6]pyrazino[2',1':3,4][1,4]diazepino[1,2-a]indole-16-carboxylate
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
Formula C22H23N3O2
Molar mass 361.445 g·mol−1
3D model (JSmol)
  • O=C(OC)C1=C2N(C3=C1C=CC=C3)CC4=CC=CC=C4N5C2CN(C)CC5
  • InChI=1S/C22H23N3O2/c1-23-11-12-24-17-9-5-3-7-15(17)13-25-18-10-6-4-8-16(18)20(22(26)27-2)21(25)19(24)14-23/h3-10,19H,11-14H2,1-2H3 checkY
  • Key:WPGUWABWNUSPMW-UHFFFAOYSA-N checkY

Serazapine (developmental code name CGS-15040A) is a serotonin 5-HT2 receptor antagonist that was investigated as a potential treatment for generalized anxiety disorder in the 1990s. In humans, serazapine was well tolerated at doses of 10 to 40 mg and was found to be superior to placebo for reducing anxiety symptoms as indicated by HAM-A scores. However, clinical development was discontinued.



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