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Atypical antipsychotic
Tenilapine
Другие языки:

Tenilapine

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Tenilapine
INN: tenilapine
Tenilapine.svg
Identifiers
  • (2E)-[5-(4-Methyl-1-piperazinyl)-9H-bisthieno[3,4-b:3',4'-e]azepin-9-ylidene]acetonitrile
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
Formula C17H16N4S2
Molar mass 340.46 g·mol−1
3D model (JSmol)
  • CN1CCN(CC1)C2=NC3=CSC=C3/C(=C/C#N)/C4=CSC=C42
  • InChI=1S/C17H16N4S2/c1-20-4-6-21(7-5-20)17-15-10-22-8-13(15)12(2-3-18)14-9-23-11-16(14)19-17/h2,8-11H,4-7H2,1H3/b12-2+
  • Key:RVQVUMIXBGFJLZ-SWGQDTFXSA-N

Tenilapine is an atypical antipsychotic which has never been marketed in the US.

Pharmacodynamics

Tenilapine has a relatively high affinity for the 5-HT2A receptor, and relatively low (micromolar) affinities for dopamine receptors.

Binding affinities
Receptor Ki (nM)
D2 1584
D4 721±300
5-HT2A 40

The ratio of D2 to D4 bonding is similar to that of clozapine. Like many other atypical antipsychotics, it is a potent 5-HT2C antagonist.


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