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Norepinephrine–dopamine reuptake inhibitors
WY-46824
Другие языки:

    WY-46824

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    WY-46824
    WY-46824.svg
    Identifiers
    • 1-[1-(3-chlorophenyl)-2-(4-methylpiperazin-1-yl)ethyl]cyclohexan-1-ol
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    ChEMBL
    CompTox Dashboard (EPA)
    Chemical and physical data
    Formula C19H29ClN2O
    Molar mass 336.90 g·mol−1
    3D model (JSmol)
    • CN1CCN(CC1)CC(C2=CC(=CC=C2)Cl)C3(CCCCC3)O
    • InChI=1S/C19H29ClN2O/c1-21-10-12-22(13-11-21)15-18(16-6-5-7-17(20)14-16)19(23)8-3-2-4-9-19/h5-7,14,18,23H,2-4,8-13,15H2,1H3
    • Key:GRUIIAQNNWQJPW-UHFFFAOYSA-N

    WY-46824 is a norepinephrine-dopamine reuptake inhibitor related to venlafaxine that was disclosed by Paige Mahaney, et al. of Wyeth in 2008. The compound actually appears in an article a year earlier in 2007 but is not the main focus of the work. It has NET binding of 46 nM, DAT = 58 nM and SERT = 18795 nM. The racemic compound was resolved into its constituent enantiomers, and the (S) enantiomer is the more active one. The N-desmethyl derivative shows similar activity.


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