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Abandoned drugs
Β-LGND2
Другие языки:

    Β-LGND2

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    Β-LGND2
    Β-LGND2.svg
    Clinical data
    Other names β-LGND2; ER-β-selective ligand 2
    Drug class Nonsteroidal estrogen; Selective ERβ agonist
    Identifiers
    • 4-bromo-6,8-dihydroxy-2-(4-hydroxyphenyl)isoquinolin-1-one
    CAS Number
    PubChem CID
    Chemical and physical data
    Formula C15H10BrNO4
    Molar mass 348.152 g·mol−1
    3D model (JSmol)
    • C1=CC(=CC=C1N2C=C(C3=CC(=CC(=C3C2=O)O)O)Br)O
    • InChI=1S/C15H10BrNO4/c16-12-7-17(8-1-3-9(18)4-2-8)15(21)14-11(12)5-10(19)6-13(14)20/h1-7,18-20H
    • Key:GLVQMSCCFOGRRG-UHFFFAOYSA-N

    β-LGND2, also known as ERβ-selective ligand 2 or as GTx-878, is a synthetic nonsteroidal estrogen and selective ERβ agonist which was under development by GTx for the treatment of benign prostatic hyperplasia, prostatitis, and rheumatoid arthritis but was never marketed. It shows approximately 25-fold selectivity for activation of the ERβ over the ERα (EC50 = 2 nM and 52 nM, respectively). β-LGND2 is an isoquinolinone derivative.

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