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Abandoned drugs
6α-Methylprogesterone
Другие языки:

    6α-Methylprogesterone

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    6α-Methylprogesterone
    6α-Methylprogesterone.svg
    Clinical data
    Other names 6α-Methylpregn-4-ene-3,20-dione; 6α-MP; 6-MP; 6MP; NSC-75530
    Drug class Progestogen; Progestin
    Identifiers
    • (6S,8S,9S,10R,13S,14S,17S)-17-acetyl-6,10,13-trimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    KEGG
    ChEBI
    ChEMBL
    Chemical and physical data
    Formula C22H32O2
    Molar mass 328.496 g·mol−1
    3D model (JSmol)
    • C[C@H]1C[C@H]2[C@@H]3CC[C@@H]([C@]3(CC[C@@H]2[C@@]4(C1=CC(=O)CC4)C)C)C(=O)C
    • InChI=1S/C22H32O2/c1-13-11-16-18-6-5-17(14(2)23)21(18,3)10-8-19(16)22(4)9-7-15(24)12-20(13)22/h12-13,16-19H,5-11H2,1-4H3/t13-,16-,17+,18-,19-,21+,22+/m0/s1
    • Key:GNFABWAPJFOZSF-KTORGGLSSA-N

    6α-Methylprogesterone (6α-MP) is a progestin which was never marketed. It has 150% of the progestogenic potency of progesterone. In addition, and in contrast to progesterone, 6α-MP has weak androgenic, antiandrogenic, and synandrogenic actions. 6α-MP is structurally related to medroxyprogesterone acetate (MPA; 6α-methyl-17α-acetoxyprogesterone) and megestrol acetate (MGA; 6-dehydro-6-methyl-17α-acetoxyprogesterone), which possess androgenic and/or antiandrogenic activity to varying degrees similarly. MPA is more androgenic than 6α-MP and MGA.



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