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Mu-opioid receptor agonists
Anileridine
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Anileridine

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Anileridine
Anileridine2DCSD.svg
Anileridine 3D BS.png
Clinical data
Trade names Leritine
AHFS/Drugs.com Monograph
Routes of
administration		 Tablets, injection
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding > 95%
Metabolism Hepatic
Identifiers
  • Ethyl 1-[2-(4-aminophenyl)ethyl]-4-phenylpiperidine-4-carboxylate
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
Formula C22H28N2O2
Molar mass 352.478 g·mol−1
3D model (JSmol)
Melting point 83 °C (181 °F)
  • O=C(OCC)C3(c1ccccc1)CCN(CCc2ccc(N)cc2)CC3
  • InChI=1S/C22H28N2O2/c1-2-26-21(25)22(19-6-4-3-5-7-19)13-16-24(17-14-22)15-12-18-8-10-20(23)11-9-18/h3-11H,2,12-17,23H2,1H3 checkY
  • Key:LKYQLAWMNBFNJT-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Anileridine (trade name: Leritine) is a synthetic analgesic drug and is a member of the piperidine class of analgesic agents developed by Merck & Co. in the 1950s. It differs from pethidine (meperidine) in that the N-methyl group of meperidine is replaced by an N-aminophenethyl group, which increases its analgesic activity.

Anileridine is no longer manufactured in the US or Canada. Anileridine is in Schedule II of the Controlled Substances Act 1970 of the United States as ACSCN 9020 with a zero aggregate manufacturing quota as of 2014. The free base conversion ratio for salts includes 0.83 for the dihydrochloride and 0.73 for the phosphate. It is also under international control per UN treaties.

Administration

As tablets or injection.

Pharmacokinetics

Anileridine usually takes effect within 15 minutes of either oral or intravenous administration, and lasts 2–3 hours. It is mostly metabolized by the liver.

See also




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