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Mu-opioid receptor agonists
N-Phenethyl-14-ethoxymetopon
Другие языки:

    N-Phenethyl-14-ethoxymetopon

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    N-Phenethyl-14-ethoxymetopon
    N-Phenethyl-14-ethoxymetopon.svg
    Identifiers
    • (5α)-14-Ethoxy-3-hydroxy-5-methyl-17-(2-phenylethyl)-4,5-epoxymorphinan-6-one
    PubChem CID
    ChemSpider
    Chemical and physical data
    Formula C27H31NO4
    Molar mass 433.548 g·mol−1
    3D model (JSmol)
    • CCO[C@@]12CCC(=O)[C@]3([C@@]14CCN([C@@H]2CC5=C4C(=C(C=C5)O)O3)CCC6=CC=CC=C6)C
    • InChI=1S/C27H31NO4/c1-3-31-27-13-11-22(30)25(2)26(27)14-16-28(15-12-18-7-5-4-6-8-18)21(27)17-19-9-10-20(29)24(32-25)23(19)26/h4-10,21,29H,3,11-17H2,1-2H3/t21-,25+,26+,27-/m1/s1 ☒N
    • Key:YNNFSTLAUJEYHI-NVSKSXHLSA-N ☒N
     ☒NcheckY (what is this?)  (verify)

    N-Phenethyl-14-ethoxymetopon is a drug that is a derivative of metopon. It is a potent analgesic, around 60 times stronger than morphine and produces significantly less constipation.

    N-Phenethyl-14-ethoxymetopon acts as an agonist at both μ- and δ-opioid receptors, with a Ki of 0.16nM at μ and 3.14nM at δ.

    See also


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