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Mu-opioid receptor agonists
C-8813
Другие языки:

    C-8813

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    C-8813
    C-8813.svg
    C-8813 3D BS.png
    Identifiers
    • trans-4-(p-Bromophenyl)-4-(dimethylamino)-1-(2-(thiophen-2-yl)ethyl)cyclohexanol
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    Chemical and physical data
    Formula C20H26BrNOS
    Molar mass 408.40 g·mol−1
    3D model (JSmol)
    • BrC1=CC=C([C@@]2(CC[C@](CC2)(CCC3=CC=CS3)O)N(C)C)C=C1
    • InChI=1S/C20H26BrNOS/c1-22(2)20(16-5-7-17(21)8-6-16)13-11-19(23,12-14-20)10-9-18-4-3-15-24-18/h3-8,15,23H,9-14H2,1-2H3/t19-,20- ☒N
    • Key:XRDNIYBVNZLPJE-MXVIHJGJSA-N ☒N
     ☒NcheckY (what is this?)  (verify)

    C-8813 (thiobromadol) is a potent μ-opioid receptor agonist with a distinctive chemical structure which is not closely related to other established families of opioid drugs. The trans-isomer was found to be around 591 times more potent than morphine in animal studies. The same study assigned a potency of 504 times that of morphine to the related compound BDPC.

    C-8813 is claimed to be similarly potent at the δ-opioid receptor, which antagonizes the mu depression of breathing, presumably making the drug safer.

    C-8813 has never been used in humans.

    See also


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