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Drotebanol
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Drotebanol

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Drotebanol
Drotebanol.svg
Clinical data
Other names Drotebanol, Oxymethebanol
AHFS/Drugs.com International Drug Names
ATC code
  • none
Legal status
Legal status
Identifiers
  • 3,4-Dimethoxy-17-methylmorphinan-6β,14-diol
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
Chemical and physical data
Formula C19H27NO4
Molar mass 333.428 g·mol−1
3D model (JSmol)
Melting point 165 to 167 °C (329 to 333 °F)
  • CN1CC[C@]23C[C@@H](CC[C@]2([C@H]1CC4=C3C(=C(C=C4)OC)OC)O)O
  • InChI=1S/C19H27NO4/c1-20-9-8-18-11-13(21)6-7-19(18,22)15(20)10-12-4-5-14(23-2)17(24-3)16(12)18/h4-5,13,15,21-22H,6-11H2,1-3H3/t13-,15-,18-,19-/m1/s1 checkY
  • Key:LCAHPIFLPICNRW-SVYNMNNPSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Drotebanol (Oxymethebanol) is a morphinan derivative that acts as an opioid agonist. It was invented by Sankyo Company in Japan during the 1970s. It is synthesised from thebaine.

Drotebanol has powerful antitussive (cough suppressant) effects, and is around 10x more potent than codeine in producing this effect. It also has analgesic effects several times stronger than codeine, but weaker than morphine. In animal studies it was found to be moderately addictive and produced limited physical dependence, but not as severe as that seen with morphine or pethidine. It was previously marketed for human use under the brand name Metebanyl, although it is now no longer used in medicine.

It is currently a Schedule I Narcotic controlled substance in the United States with a DEA ACSCN of 9335 and an annual aggregate manufacturing quota of zero.



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