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Abandoned drugs
Fedotozine
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    Fedotozine

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    Fedotozine
    Fedotozine structure.svg
    Clinical data
    Routes of
    administration    		 Oral
    ATC code
    • None
    Legal status
    Legal status
    • In general: non-regulated
    Identifiers
    • (2R)-N,N-dimethyl-2-phenyl-1-[(3,4,5-trimethoxybenzyl)oxy]-2-butanamine
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    ChEMBL
    Chemical and physical data
    Formula C22H31NO4
    Molar mass 373.493 g·mol−1
    3D model (JSmol)
    • O(c1cc(cc(OC)c1OC)COC[C@@](c2ccccc2)(N(C)C)CC)C
    • InChI=1S/C22H31NO4/c1-7-22(23(2)3,18-11-9-8-10-12-18)16-27-15-17-13-19(24-4)21(26-6)20(14-17)25-5/h8-14H,7,15-16H2,1-6H3/t22-/m0/s1
    • Key:MVKIWCDXKCUDEH-QFIPXVFZSA-N

    Fedotozine (INN; JO 1196 for the (-) tartrate salt) is an opioid drug of the arylacetamide series which acts as a peripherally specific selective κ1-opioid receptor agonist with preference for the κ1A subtype. It was under investigation for the treatment of gastrointestinal conditions like irritable bowel syndrome and functional dyspepsia and made it to phase III clinical trials, but ultimately development was discontinued and it was never marketed.

    See also


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