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Mu-opioid receptor agonists
Piperidylthiambutene
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    Piperidylthiambutene

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    Piperidylthiambutene
    Piperidylthiambutene Structure.svg
    Clinical data
    ATC code
    • none
    Identifiers
    • 1-[4,4-Di(thiophen-2-yl)but-3-en-2-yl]piperidine
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    Chemical and physical data
    Formula C17H21NS2
    Molar mass 303.48 g·mol−1
    3D model (JSmol)
    Melting point 188 to 189 °C (370 to 372 °F)
    • C1CCCCN1C(C)C=C(c3cccs3)c2sccc2
    • InChI=1S/C17H21NS2/c1-14(18-9-3-2-4-10-18)13-15(16-7-5-11-19-16)17-8-6-12-20-17/h5-8,11-14H,2-4,9-10H2,1H3
    • Key:FQRWJLVMJCKSME-UHFFFAOYSA-N
      (verify)

    Piperidylthiambutene (Piperidinohton) is a syntheticopioid analgesic drug from the thiambutene family, which has around the same potency as morphine. Piperidylthiambutene is structurally distinct from fentanyl, its analogues, and other synthetic opioids previously reported. If sold or obtained for the purpose of human consumption it could be considered a controlled substance analogue in some countries such as the US, Australia and New Zealand. Piperidylthiambutene has been sold as a designer drug, first appearing in late 2018.

    Synthesis

    Patent:

    The Grignard reaction between 3-Piperidinobutyric acid ethyl ester, CID:10774378 (1) and 2-Bromothiophene [1003-09-4] (2) gives 3. Dehydration in acid completes the synthesis.


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