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Tricyclic antidepressant
Quinupramine
Другие языки:

Quinupramine

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Quinupramine
Quinupramine.svg
Clinical data
Routes of
administration		 Oral
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Elimination half-life 33 hours
Identifiers
  • (±)-11-quinuclidin-3-yl-5,6-dihydrobenzo[b][1]benzazepine
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ECHA InfoCard 100.046.149
Chemical and physical data
Formula C21H24N2
Molar mass 304.437 g·mol−1

Quinupramine (brand names Kevopril, Kinupril, Adeprim, Quinuprine) is a tricyclic antidepressant (TCA) used in Europe for the treatment of depression.

Pharmacologically, quinupramine acts in vitro as a strong muscarinic acetylcholine receptor antagonist (anticholinergic) and H1 receptor antagonist (antihistamine), moderate 5-HT2 receptor antagonist, and weak serotonin and norepinephrine reuptake inhibitor. It has negligible affinity for the α1-adrenergic, α2-adrenergic, β-adrenergic, or D2 receptor.

Clinically, quinupramine is reported to be stimulating similarly to imipramine, desipramine, and demexiptiline. It can be inferred that its in vivo metabolites may have stronger effects on the reuptake of norepinephrine and/or serotonin than quinupramine itself.



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