Zinc finger protein 208

ZNF208
Identifiers
Aliases	ZNF208, PMIDP, ZNF95, zinc finger protein 208
External IDs	OMIM: 603977 MGI: 1917477 HomoloGene: 133818 GeneCards: ZNF208
Gene location (Human) Chr. Chromosome 19 (human) Band 19p12 Start 21,932,958 bp End 22,010,949 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 B3 Start 39,167,190 bp End 39,189,844 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ventricle anterior pituitary left lobe of thyroid gland islet of Langerhans right uterine tube right lobe of thyroid gland left coronary artery left uterine tube ascending aorta smooth muscle tissue Top expressed in trigeminal ganglion medial ganglionic eminence triceps brachii muscle digastric muscle vastus lateralis muscle carotid body superior frontal gyrus neural tube sternocleidomastoid muscle temporal muscle More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding zinc ion binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component intracellular anatomical structure nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7757 70227 Ensembl ENSG00000160321 ENSMUSG00000068959 UniProt O43345 n/a RefSeq (mRNA) NM_001329971 NM_001329972 NM_001329973 NM_001329974 NM_007153 NM_001004139 RefSeq (protein) NP_001316900 NP_001316901 NP_001316902 NP_001316903 NP_009084 n/a Location (UCSC) Chr 19: 21.93 – 22.01 Mb Chr 7: 39.17 – 39.19 Mb PubMed search
Wikidata
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Zinc finger protein 208 is a protein that in humans is encoded by the ZNF208 gene.

Function

Zinc finger proteins (ZNFs), such as ZNF208, bind DNA and, through this binding, regulate gene transcription. Most ZNFs contain conserved C2H2 motifs and are classified as Kruppel-type zinc fingers. A conserved protein motif, termed the Kruppel-associated box (KRAB) domain, mediates protein-protein interactions (Eichler et al., 1998 [PubMed 9724325]). See ZNF91 (MIM 603971) for further information on ZNFs.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.