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Androgens and anabolic steroids
Atamestane
Другие языки:

    Atamestane

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    Atamestane
    Atamestane.svg
    Clinical data
    Other names SH-489; Metandroden; 1-Methylandrosta-1,4-diene-3,17-dione
    ATC code
    • None
    Legal status
    Legal status
    Identifiers
    • (8R,9S,10S,13S,14S)-1,10,13-Trimethyl-7,8,9,11,12, 14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-dione
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    ChEMBL
    Chemical and physical data
    Formula C20H26O2
    Molar mass 298.426 g·mol−1
    3D model (JSmol)
    • O=C\1/C=C(/C)[C@]4(C(=C/1)/CC[C@@H]3[C@@H]4CC[C@@]2(C(=O)CC[C@H]23)C)C
    • InChI=1S/C20H26O2/c1-12-10-14(21)11-13-4-5-15-16-6-7-18(22)19(16,2)9-8-17(15)20(12,13)3/h10-11,15-17H,4-9H2,1-3H3/t15-,16-,17-,19-,20-/m0/s1 checkY
    • Key:PEPMWUSGRKINHX-TXTPUJOMSA-N checkY
     ☒NcheckY (what is this?)  (verify)

    Atamestane (developmental code name SH-489), also known as metandroden, as well as 1-methylandrosta-1,4-diene-3,17-dione, is a steroidal aromatase inhibitor that was studied in the treatment of cancer. It blocks the production of estrogen in the body. The drug is selective, competitive, and irreversible in its inhibition of aromatase.

    See also

    • Boldione (androsta-1,4-diene-3,17-dione)

    External links

    • Atamestane entry in the public domain NCI Dictionary of Cancer Terms

    Public Domain This article incorporates public domain material from Dictionary of Cancer Terms. U.S. National Cancer Institute.


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