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Abandoned drugs
Broparestrol
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    Broparestrol

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    Broparestrol
    Broparestrol.svg
    Clinical data
    Trade names Acnestrol, Longestrol
    Other names LN-107; α-Bromo-α,β-diphenyl-β-p-ethylphenylethylene; BDPE
    Pregnancy
    category
    • X (Contraindicated)
    Routes of
    administration    		 By mouth
    Drug class Selective estrogen receptor modulator
    Legal status
    Legal status
    • In general: ℞ (Prescription only)
    Identifiers
    • 1-(2-bromo-1,2-diphenylethenyl)-4-ethylbenzene
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    Chemical and physical data
    Formula C22H19Br
    Molar mass 363.298 g·mol−1
    3D model (JSmol)
    • CCc1ccc(cc1)/C(=C(\c2ccccc2)/Br)/c3ccccc3
    • InChI=1S/C22H19Br/c1-2-17-13-15-19(16-14-17)21(18-9-5-3-6-10-18)22(23)20-11-7-4-8-12-20/h3-16H,2H2,1H3/b22-21+
    • Key:OQCYTSHIQNPJIC-QURGRASLSA-N

    Broparestrol (INN) (brand names Acnestrol, Longestrol; former developmental code name LN-107), also known as α-bromo-α,β-diphenyl-β-p-ethylphenylethylene (BDPE), is a synthetic, nonsteroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group that has been used in Europe as a dermatological agent and for the treatment of breast cancer. The drug is described as slightly estrogenic and potently antiestrogenic, and inhibits mammary gland development and suppresses prolactin levels in animals. It is structurally related to clomifene and diethylstilbestrol. Broparestrol is a mixture of E- and Z- isomers (LN-1643 and LN-2299, respectively), both of which are active and are similarly antiestrogenic but, unlike broparestrol, were never marketed.

    See also



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