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Pharmacology stubs
Colforsin daropate
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Colforsin daropate

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Colforsin daropate
Colforsin.png
Clinical data
AHFS/Drugs.com International Drug Names
ATC code
  • none
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-acetyloxy-3-ethenyl-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-6-yl] 3-dimethylaminopropanoate
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard 100.215.763
Chemical and physical data
Formula C27H43NO8
Molar mass 509.640 g·mol−1
3D model (JSmol)
  • CC(=O)O[C@H]1[C@H]([C@H]2C(CC[C@@H]([C@@]2([C@@]3([C@@]1(O[C@@](CC3=O)(C)C=C)C)O)C)O)(C)C)OC(=O)CCN(C)C
  • InChI=1S/C27H43NO8/c1-10-24(5)15-18(31)27(33)25(6)17(30)11-13-23(3,4)21(25)20(35-19(32)12-14-28(8)9)22(34-16(2)29)26(27,7)36-24/h10,17,20-22,30,33H,1,11-15H2,2-9H3/t17-,20-,21-,22-,24-,25-,26+,27-/m0/s1 ☒N
  • Key:RSOZZQTUMVBTMR-XGUNBQNXSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Colforsin daropate is a carboxylic ester derived from the condensation of forskolin (colforsin) with N,N-dimethyl-β-alanine.

Its water-soluble hydrochloride salt (NKH 477) is an adenylyl cyclase activator which has been studied for its cardiac selectivity.

Its parent compound forskolin (colforsin) is also used to raise levels of cAMP in the study of cell physiology.



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