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Anti-acne preparations
Delanterone
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Delanterone

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Delanterone
Delanterone.svg
Clinical data
Other names GBR-21162; 1α-Methylandrosta-4,16-dien-3-one
Identifiers
  • (1S,8S,9S,10R,13R,14S)-1,10,13-trimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthren-3-one
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
Formula C20H28O
Molar mass 284.443 g·mol−1
3D model (JSmol)
  • CC1CC(=O)C=C2C1(C3CCC4(C=CCC4C3CC2)C)C
  • InChI=1S/C20H28O/c1-13-11-15(21)12-14-6-7-16-17-5-4-9-19(17,2)10-8-18(16)20(13,14)3/h4,9,12-13,16-18H,5-8,10-11H2,1-3H3/t13-,16-,17-,18-,19-,20-/m0/s1
  • Key:GDONNNQFENTLQC-VWTPSIDOSA-N

Delanterone (INN) (developmental code name GBR-21162), also known as 1α-methylandrosta-4,16-dien-3-one, is a steroidal antiandrogen described as an anti-acne agent which was never marketed. The compound showed poor efficacy as an antiandrogen in vivo in animals, suggestive of low activity or a short terminal half-life, and likely in relation to this was not further developed. It was described and characterized in the literature in 1977.

See also


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