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Abandoned drugs
DHA-clozapine
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    DHA-clozapine

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    DHA-clozapine
    Docosahexaenoyl-clozapine.svg
    Clinical data
    Trade names Clozaprexin
    Other names Docosahexaenoyl clozapine
    ATC code
    • none
    Legal status
    Legal status
    Identifiers
    • (4Z,7Z,10Z,13Z,16Z,19Z)-1-[3-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzodiazepin-11-yl]docosa-4,7,10,13,16,19-hexaen-1-one
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    Chemical and physical data
    Formula C40H49ClN4O
    Molar mass 637.31 g·mol−1
    3D model (JSmol)
    • Clc1ccc2N(C(=O)CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CC)c4ccccc4C(=N/c2c1)\N3CCN(C)CC3
    • InChI=1S/C40H49ClN4O/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-26-39(46)45-37-25-23-22-24-35(37)40(44-31-29-43(2)30-32-44)42-36-33-34(41)27-28-38(36)45/h4-5,7-8,10-11,13-14,16-17,19-20,22-25,27-28,33H,3,6,9,12,15,18,21,26,29-32H2,1-2H3/b5-4-,8-7-,11-10-,14-13-,17-16-,20-19- ☒N
    • Key:RPSJOJIGGSRDMO-JDPCYWKWSA-N ☒N
     ☒NcheckY (what is this?)  (verify)

    DHA-clozapine (tentative trade name Clozaprexin) is an atypical antipsychotic drug candidate that was created and originally tested by chemists at Protarga, a small pharmaceutical in Pennsylvania, and scientists at Harvard University.

    It is a prodrug of clozapine; the fatty acid docosahexaenoic acid (DHA) was added to clozapine in order to increase penetration of the blood–brain barrier.

    Protarga was purchased by Luitpold Pharmaceuticals in 2003 and development was discontinued in 2007.



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