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Abandoned drugs
Estradiol benzoate/estradiol valerate/hydroxyprogesterone caproate
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    Estradiol benzoate/estradiol valerate/hydroxyprogesterone caproate

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    Estradiol benzoate /
    estradiol valerate /
    hydroxyprogesterone caproate
    Combination of
    Estradiol benzoate Estrogen
    Estradiol valerate Estrogen
    Hydroxyprogesterone caproate Progestogen
    Clinical data
    Trade names Sin-Ol
    Other names EB/EV/OHPC
    Routes of
    administration    		 Intramuscular injection

    Estradiol benzoate/estradiol valerate/hydroxyprogesterone caproate (EB/EV/OHPC), sold under the brand name Sin-Ol, is a combination medication of estradiol benzoate (EB), an estrogen, estradiol valerate (EV), an estrogen, and hydroxyprogesterone caproate (OHPC), a progestin, which was reportedly used as a combined injectable contraceptive in women in the early 1970s. It contained 1 mg EB, 10 mg EV, and 250 mg OHPC in oil solution, was provided in the form of 3 mL ampoules, and was administered by intramuscular injection at regular intervals. The medication was manufactured by the pharmaceutical company Reuffer in Mexico.

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