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Combined estrogen–progestogen formulations
Estradiol benzoate/hydroxyprogesterone caproate
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    Estradiol benzoate/hydroxyprogesterone caproate

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    Estradiol benzoate /
    hydroxyprogesterone caproate
    Estradiol benzoate.svg
    Hydroxyprogesterone caproate.svg
    Estradiol benzoate (top) and
    hydroxyprogesterone caproate (bottom)
    Combination of
    Estradiol benzoate Estrogen
    Hydroxyprogesterone caproate Progestogen
    Clinical data
    Trade names Primosiston, others
    Other names EB/OHPC
    Routes of
    administration    		 Intramuscular injection
    ATC code
    Identifiers
    CAS Number
    PubChem CID
    PubChem SID
    ChemSpider
    KEGG

    Estradiol benzoate/hydroxyprogesterone caproate (EB/OHPC), sold under the brand name Primosiston among others, is a combined estrogen and progestogen medication which is used to treat gynecological disorders and habitual abortion. It contains estradiol benzoate (EB), an estrogen, and hydroxyprogesterone caproate (OHPC), a progestin. The medication is given by injection into muscle.

    Medical uses

    EB/OHPC is used in the treatment of gynecological disorders such as menstrual disorders (e.g., amenorrhea, dysfunctional uterine bleeding) and premenstrual syndrome, habitual abortion (threatened miscarriage), and for other indications.

    Available forms

    EB/OHPC is available in the form of ampoules of oil solutions containing 10 mg estradiol benzoate (EB) and 125 to 250 mg hydroxyprogesterone caproate (OHPC).

    History

    EB/OHPC was first introduced for medical use in 1955.

    Society and culture

    Brand names

    EB/OHPC has been marketed under brand names including Dos Dias N, Lutes, Ostrolut, Primosiston (or Primosiston Inj. / Injection), Primosiston Fuerte, and Syngynon.

    Availability

    EB/OHPC has been mostly discontinued and hence is mostly no longer available. It remains marketed under the brand names Primosiston in Ecuador and Peru, Dos Dias N in Argentina, and Lutes in Japan. It was previously marketed under the brand names Ostrolut in Austria; Primosiston (or Primosiston Inj. / Injection) (Schering) in Argentina, Germany, Mexico, Switzerland, and Venezuela; Primosiston Fuerte in Spain; and Syngynon in Germany, but these formulations have all been discontinued and hence are no longer available in these countries.

    See also


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