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Estradiol butyrylacetate/testosterone ketolaurate/reserpine
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    Estradiol butyrylacetate/testosterone ketolaurate/reserpine

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    Estradiol butyrylacetate /
    testosterone ketolaurate
    Estradiol butyrylacetate.svg
    Testosterone ketolaurate.svg
    Combination of
    Estradiol butyrylacetate Estrogen
    Testosterone ketolaurate Androgen; Anabolic steroid
    Reserpine Antipsychotic
    Clinical data
    Trade names Klimanosid R-Depot
    Other names EBA/TKL; EBA/TCA
    Routes of
    administration
    Intramuscular injection

    Estradiol butyrylacetate/testosterone ketolaurate/reserpine (EBA/TKL/R), sold under the brand name Klimanosid R-Depot, is an injectable combination medication of estradiol butyrylacetate (EBA), an estrogen, testosterone ketolaurate (TKL; testosterone caprinoylacetate), an androgen/anabolic steroid, and reserpine, an antipsychotic, which was previously used in menopausal hormone therapy for women, particularly in those with pronounced neurovegetative symptoms. It contains 2 mg EBA, 50 mg TKL, and 0.4 mg reserpine in oil solution in each 1 mL ampoule and is administered by intramuscular injection at regular intervals. The medication was marketed in 1957.

    EBA/TKL reportedly has a duration of about 21 days.

    Oral tablet products with the same brand names of Klimanosid and Klimanosid R, containing methylestradiol and methyltestosterone, with and without reserpine, were marketed around the same time as Klimanosid-R Depot, and should not be confused with the injectable formulation.

    Androgen replacement therapy formulations and dosages used in women
    Route Medication Major brand names Form Dosage
    Oral Testosterone undecanoate Andriol, Jatenzo Capsule 40–80 mg 1x/1–2 days
    Methyltestosterone Metandren, Estratest Tablet 0.5–10 mg/day
    Fluoxymesterone Halotestin Tablet 1–2.5 mg 1x/1–2 days
    Normethandronea Ginecoside Tablet 5 mg/day
    Tibolone Livial Tablet 1.25–2.5 mg/day
    Prasterone (DHEA)b Tablet 10–100 mg/day
    Sublingual Methyltestosterone Metandren Tablet 0.25 mg/day
    Transdermal Testosterone Intrinsa Patch 150–300 μg/day
    AndroGel Gel, cream 1–10 mg/day
    Vaginal Prasterone (DHEA) Intrarosa Insert 6.5 mg/day
    Injection Testosterone propionatea Testoviron Oil solution 25 mg 1x/1–2 weeks
    Testosterone enanthate Delatestryl, Primodian Depot Oil solution 25–100 mg 1x/4–6 weeks
    Testosterone cypionate Depo-Testosterone, Depo-Testadiol Oil solution 25–100 mg 1x/4–6 weeks
    Testosterone isobutyratea Femandren M, Folivirin Aqueous suspension 25–50 mg 1x/4–6 weeks
    Mixed testosterone esters Climacterona Oil solution 150 mg 1x/4–8 weeks
    Omnadren, Sustanon Oil solution 50–100 mg 1x/4–6 weeks
    Nandrolone decanoate Deca-Durabolin Oil solution 25–50 mg 1x/6–12 weeks
    Prasterone enanthatea Gynodian Depot Oil solution 200 mg 1x/4–6 weeks
    Implant Testosterone Testopel Pellet 50–100 mg 1x/3–6 months
    Notes: Premenopausal women produce about 230 ± 70 μg testosterone per day (6.4 ± 2.0 mg testosterone per 4 weeks), with a range of 130 to 330 μg per day (3.6–9.2 mg per 4 weeks). Footnotes: a = Mostly discontinued or unavailable. b = Over-the-counter. Sources: See template.

    See also



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