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Abandoned drugs
Estrapronicate/hydroxyprogesterone heptanoate/nandrolone undecanoate
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    Estrapronicate/hydroxyprogesterone heptanoate/nandrolone undecanoate

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    EPC/OHPH/NU
    Combination of
    Estrapronicate Estrogen
    Hydroxyprogesterone heptanoate Progestogen
    Nandrolone undecanoate Androgen; Anabolic steroid
    Clinical data
    Trade names Trophobolene, Trophoboline
    Other names EPC/OHPH/NU
    Routes of
    administration    		 Intramuscular injection
    Identifiers
    CAS Number

    Estrapronicate/hydroxyprogesterone heptanoate/nandrolone undecanoate (EPC/OHPH/NU), tentative brand name Trophobolene or Trophoboline, is an injectable combination medication of estrapronicate (EPC; estradiol nicotinate propionate), an estrogen, hydroxyprogesterone heptanoate (OHPH), a progestogen, and nandrolone undecanoate (NU), an androgen/anabolic steroid, which was never marketed. It contained 1.3 mg EPC, 80 mg OHPH, and 50 mg NU in oil solution and was administered by intramuscular injection. The medication was developed by Théramex in the mid-to-late 1960s. It was studied for use for a variety of indications, including treatment of coronary insufficiency, growth deficiency, and osteoporosis, as well as hormonal disorders in gonadotropin deficiency.

    In contrast to other anabolic steroid-containing preparations, EPC/OHPH/NU reportedly had no masculinizing effects, and its estrogenic component likewise reportedly had no feminizing effects. The nicotinic acid (niacin; vitamin B3) derived from estrapronicate was said to enhance the nutrient, relaxant, and antiadipose effects of the estrogenic component.

    The pharmacokinetics of nandrolone undecanoate in this combination preparation have been studied as well as compared to nandrolone alone (Dynabolon).

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