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Abandoned drugs
Estriol dipropionate
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    Estriol dipropionate

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    Estriol dipropionate
    Estriol 3,17-dipropionate.svg
    Clinical data
    Other names Oestriol dipropionate; Estriol 3,17β-dipropionate; 16α-Hydroxyestra-1,3,5(10)-triene-3,17β-diyl dipropanoate
    Routes of
    administration    		 Intramuscular injection
    Drug class Estrogen; Estrogen ester
    Identifiers
    • [(8R,9S,13S,14S,16R,17R)-16-hydroxy-13-methyl-3-propanoyloxy-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] propanoate
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    Chemical and physical data
    Formula C24H32O5
    Molar mass 400.515 g·mol−1
    3D model (JSmol)
    • CCC(=O)O[C@H]1[C@@H](C[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=C3C=CC(=C4)OC(=O)CC)C)O
    • InChI=1S/C24H32O5/c1-4-21(26)28-15-7-9-16-14(12-15)6-8-18-17(16)10-11-24(3)19(18)13-20(25)23(24)29-22(27)5-2/h7,9,12,17-20,23,25H,4-6,8,10-11,13H2,1-3H3/t17-,18-,19+,20-,23+,24+/m1/s1
    • Key:QKLDCEYHDKPVDK-PRIYMHJNSA-N

    Estriol dipropionate, or estriol 3,17β-dipropionate, is a synthetic estrogen and estrogen ester – specifically, the C3 and C17β dipropionate ester of estriol – which was first described in 1963 and was never marketed. Following a single intramuscular injection of 6.94 mg estriol dipropionate (equivalent to 5.0 mg estriol) in an oil solution, peak levels of estriol occurred after 0.83 days, an elimination half-life of 12.7 hours was observed, and estriol levels remained elevated for up to 4 days. For comparison, the duration of estriol was much shorter, while that of estriol dihexanoate was much longer.

    See also



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