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Combined estrogen–progestogen–androgen formulations
Ethinylestradiol/drospirenone/prasterone
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    Ethinylestradiol/drospirenone/prasterone

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    Ethinylestradiol /
    drospirenone / prasterone
    Combination of
    Ethinylestradiol Estrogen
    Drospirenone Progestogen; Progestin; Antimineralocorticoid; Antiandrogen
    Prasterone Androgen; Anabolic steroid; Androgen prohormone; Neurosteroid
    Clinical data
    Other names EE/DRSP/DHEA; Androgen Restored Contraceptive; ARC; Female Balance Pill; Pill-Plus; Triple Oral Contraceptive; Triple OC
    Routes of
    administration    		 By mouth
    Drug class Estrogen; Progestin; Progestogen; Antimineralocorticoid; Androgen; Anabolic steroid
    Legal status
    Legal status

    Ethinylestradiol/drospirenone/prasterone (EE/DRSP/DHEA), known under developmental code names like Androgen Restored Contraceptive (ARC), Female Balance Pill, Pill-Plus, and Triple Oral Contraceptive (Triple OC), is a combination of ethinylestradiol (EE), an estrogen, drospirenone (DRSP), a progestin, antimineralocorticoid, and antiandrogen, and prasterone (dehydroepiandrosterone; DHEA), an androgen prohormone and neurosteroid, which is under development for use as a birth control pill to prevent pregnancy in women. Clinical studies of this formulation have been conducted and published. Estrogens and progestogens suppress testosterone levels in women, and the addition of 50 mg prasterone, an oral prohormone of testosterone, has been found to restore total testosterone levels to normal levels. However, free testosterone levels, although higher with the addition of prasterone, remain significantly lower than usual despite prasterone inclusion.

    See also

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