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Mu-opioid receptor agonists
IC-26
Другие языки:

    IC-26

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    For other uses, see IC 26 (disambiguation).
    IC-26
    IC-26 structure.svg
    Identifiers
    • 4-ethylsulfonyl-N,N-dimethyl-4,4-diphenylbutan-2-amine
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    Chemical and physical data
    Formula C20H27NO2S
    Molar mass 345.50 g·mol−1
    3D model (JSmol)
    • CCS(=O)(=O)C(CC(C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2
    • InChI=1S/C20H27NO2S/c1-5-24(22,23)20(16-17(2)21(3)4,18-12-8-6-9-13-18)19-14-10-7-11-15-19/h6-15,17H,5,16H2,1-4H3
    • Key:NLPGJSPLDNDKKZ-UHFFFAOYSA-N
      (verify)

    IC-26 (WIN 1161-3, Methiodone) is an analogue of the opioid analgesic methadone, where the carbonyl group has been replaced by the bioisosteric sulfone group.

    Human and animal studies suggest that IC-26 is around the same potency as methadone, although other studies have found its activity to be inconsistent between different patients, with consistent opioid activity only being seen at a dose several times that of methadone. IC-26 was assessed for its abuse potential, but despite being found to have similar potential to methadone for development of dependence it was never placed under international control as an illegal drug.

    See also


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