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Abandoned drugs
LS-1727
Другие языки:

    LS-1727

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    LS-1727
    LS-1727.svg
    Clinical data
    Other names LEO-1727; 19-Nortestosterone 17β-N-(2-chloroethyl)-N-nitrosocarbamate; Nandrolone chloroethylnitrosocarbamate
    Routes of
    administration    		 Intramuscular injection
    Drug class Cytostatic antineoplastic agent; Androgen; Anabolic steroid; Androgen ester; Progestogen
    Identifiers
    • [(8R,9S,10R,13S,14S,17S)-13-methyl-3-oxo-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl] N-(2-chloroethyl)-N-nitrosocarbamate
    CAS Number
    PubChem CID
    ChemSpider
    CompTox Dashboard (EPA)
    Chemical and physical data
    Formula C21H29ClN2O4
    Molar mass 408.92 g·mol−1
    3D model (JSmol)
    • C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2OC(=O)N(CCCl)N=O)CCC4=CC(=O)CC[C@H]34
    • InChI=1S/C21H29ClN2O4/c1-21-9-8-16-15-5-3-14(25)12-13(15)2-4-17(16)18(21)6-7-19(21)28-20(26)24(23-27)11-10-22/h12,15-19H,2-11H2,1H3/t15-,16+,17+,18-,19-,21-/m0/s1
    • Key:KTQUNVRSLAGBSY-RRFJAZBJSA-N

    LS-1727 (also known as nandrolone 17β-N-(2-chloroethyl)-N-nitrosocarbamate) is a synthetic, injected anabolic–androgenic steroid (AAS) and a nitrosocarbamate ester of nandrolone (19-nortestosterone) which was developed as a cytostatic antineoplastic agent but was never marketed.

    Relative affinities (%) of nandrolone and related steroids
    Compound PR AR ER GR MR SHBG CBG
    Nandrolone 20 154–155 <0.1 0.5 1.6 1–16 0.1
    Testosterone 1.0–1.2 100 <0.1 0.17 0.9 19–82 3–8
    Estradiol 2.6 7.9 100 0.6 0.13 8.7–12 <0.1
    Notes: Values are percentages (%). Reference ligands (100%) were progesterone for the PR, testosterone for the AR, estradiol for the ER, dexamethasone for the GR, aldosterone for the MR, dihydrotestosterone for SHBG, and cortisol for CBG. Sources: See template.

    See also


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